Effect of Respiratory Impairment on the Outcomes of Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction and Coronavirus Disease-2019 (COVID-19)

Background:Coronavirus Disease-2019 (COVID-19) may impair outcomes of patients with ST-segment elevation myocardial infarction (STEMI). The extent of this phenomenon and its mechanisms are unclear.Methods and Results:This study prospectively included 50 consecutive STEMI patients admitted to our cen...

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Veröffentlicht in:	Circulation Journal 2021/09/24, Vol.85(10), pp.1701-1707
Hauptverfasser:	Pellegrini, Dario, Fiocca, Luigi, Pescetelli, Irene, Canova, Paolo, Vassileva, Angelina, Faggi, Lara, Senni, Michele, Guagliumi, Giulio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Acute myocardial infarction Aged Aged, 80 and over Cause of Death Coronary revascularization COVID-19 - diagnosis COVID-19 - mortality COVID-19 - physiopathology COVID-19 - virology Female Hospital Mortality Humans Lung - physiopathology Lung - virology Male Middle Aged Percutaneous coronary intervention Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - mortality Prospective Studies Respiration Respiratory Insufficiency - diagnosis Respiratory Insufficiency - mortality Respiratory Insufficiency - physiopathology Respiratory Insufficiency - virology Risk Assessment Risk Factors SARS-COV2 ST Elevation Myocardial Infarction - diagnostic imaging ST Elevation Myocardial Infarction - mortality ST Elevation Myocardial Infarction - physiopathology ST Elevation Myocardial Infarction - therapy Time Factors Treatment Outcome
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Zusammenfassung:	Background:Coronavirus Disease-2019 (COVID-19) may impair outcomes of patients with ST-segment elevation myocardial infarction (STEMI). The extent of this phenomenon and its mechanisms are unclear.Methods and Results:This study prospectively included 50 consecutive STEMI patients admitted to our center for primary percutaneous coronary intervention (PCI) at the peak of the Italian COVID-19 outbreak. At admission, a COVID-19 test was positive in 24 patients (48%), negative in 26 (52%). The primary endpoint was in-hospital all-cause mortality. Upon admission, COVID-19 subjects had lower PO2/FiO2 (169 [100–425] vs. 390 [302–477], P
ISSN:	1346-9843 1347-4820 1347-4820
DOI:	10.1253/circj.CJ-20-1166