Error-Free Synthetic DNA by Molecular Dictation

Synthetic DNA is the linchpin of the rapidly accelerating biotechnological era and is perhaps the most promising candidate for long-term digital data storage. Despite huge advances, manufacturing error-free DNA at low cost and high throughput remains challenging. Borrowing from well-established sequ...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2021-09, Vol.39 (9), p.861-865
Hauptverfasser:	Knyphausen, Philipp, Lindenburg, Laurens, Hollfelder, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Biotechnology Data storage Deoxyribonucleic acid Digital data DNA DNA sequencing DNA synthesis Enzymes Error correction Error correction & detection Methods synthetic biology
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Beschreibung
Zusammenfassung:	Synthetic DNA is the linchpin of the rapidly accelerating biotechnological era and is perhaps the most promising candidate for long-term digital data storage. Despite huge advances, manufacturing error-free DNA at low cost and high throughput remains challenging. Borrowing from well-established sequencing-by-synthesis technologies, we describe a new solution for DNA error correction.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2021.02.001