Metabolic Regulation of Intestinal Stem Cell Homeostasis

The balance between self-renewal and differentiation of intestinal stem cells is essential for intestinal epithelial homeostasis, which can be regulated by dietary cues. Recent evidences indicate that metabolic pathways sense changes in nutritional status to control stem cell fate, which may provide...

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Veröffentlicht in:Trends in cell biology 2021-05, Vol.31 (5), p.325-327
Hauptverfasser: Wang, Dan, Odle, Jack, Liu, Yulan
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container_title Trends in cell biology
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creator Wang, Dan
Odle, Jack
Liu, Yulan
description The balance between self-renewal and differentiation of intestinal stem cells is essential for intestinal epithelial homeostasis, which can be regulated by dietary cues. Recent evidences indicate that metabolic pathways sense changes in nutritional status to control stem cell fate, which may provide new clues for the prevention of intestinal diseases.
doi_str_mv 10.1016/j.tcb.2021.02.001
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source Elsevier ScienceDirect Journals
subjects Cell differentiation
Cell fate
Cell self-renewal
Diet
differentiation, nutrition
Homeostasis
intestinal stem cells
Intestine
Metabolic pathways
Metabolism
Nutritional status
self-renewal
Stem cells
title Metabolic Regulation of Intestinal Stem Cell Homeostasis
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