Metabolic Regulation of Intestinal Stem Cell Homeostasis

Metabolic Regulation of Intestinal Stem Cell Homeostasis

The balance between self-renewal and differentiation of intestinal stem cells is essential for intestinal epithelial homeostasis, which can be regulated by dietary cues. Recent evidences indicate that metabolic pathways sense changes in nutritional status to control stem cell fate, which may provide...

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Veröffentlicht in:Trends in cell biology 2021-05, Vol.31 (5), p.325-327
Hauptverfasser: Wang, Dan, Odle, Jack, Liu, Yulan
Format: Artikel
Sprache:eng
Schlagworte:
Cell differentiation
Cell fate
Cell self-renewal
Diet
differentiation, nutrition
Homeostasis
intestinal stem cells
Intestine
Metabolic pathways
Metabolism
Nutritional status
self-renewal
Stem cells
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Zusammenfassung:The balance between self-renewal and differentiation of intestinal stem cells is essential for intestinal epithelial homeostasis, which can be regulated by dietary cues. Recent evidences indicate that metabolic pathways sense changes in nutritional status to control stem cell fate, which may provide new clues for the prevention of intestinal diseases.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2021.02.001