Retrieval-extinction as a reconsolidation-based treatment for emotional disorders:Evidence from an extinction retention test shortly after intervention

The retrieval-extinction paradigm, a non-invasive memory intervention that is methodologically similar to exposure therapy, has significant clinical application prospects for targeting memory reconsolidation. However, it is difficult to distinguish whether the effect of preventing the return of fear by retrieval-extinction depends upon the reconsolidation-based mechanism or extinction-based mechanism. This study tested extinction retention shortly after intervention to determine whether retrieval-extinction is a reconsolidation-based approach or extinction-based approach as well as exploring the effect of sleep. In our experiment, the effects on fear conditional memory of standard extinction, retrieval-extinction, and extinction-retrieval were compared using the fear test at 3 h, 12 h without a night's sleep, and 12 h with a night's sleep after the intervention. The results showed that standard extinction and extinction-retrieval procedures reduce fear 3 h after intervention, while retrieval-extinction procedure reduces fear 12 h with a night's sleep after the intervention. The results suggest that standard extinction and extinction-retrieval create an extinction memory trace that competes with original memory trace, only retrieval-extinction update the original memory trace through memory reconsolidation. These findings provide solid evidence for the reconsolidation mechanism of the retrieval-extinction paradigm and highlight the effect of sleep on memory reconsolidation. •Both retrieval-extinction and extinction-retrieval procedures can prevent fear relapse.•Fear reduction effect of standard extinction and extinction-retrieval are apparent immediately after intervention.•Fear reduction effect of retrieval-extinction is not apparent immediately after intervention.•One night of sleep is necessary to observe the retrieval-extinction effect of fear reduction.