Prognostic value of intraductal carcinoma for adjuvant radiotherapy candidates after radical prostatectomy

Objective To investigate the prognostic significance of intraductal carcinoma of the prostate (IDC‐P) in radical prostatectomy (RP) specimens and predictive value of IDC‐P for biochemical recurrence and adjuvant therapy decision. Method We retrospectively evaluated patients who were performed RP between 2000 and 2014. Among, 67 patients who had stage pT3a tumour with negative surgical margin (Group 1, n = 35) and who had stage pT2 tumour with positive surgical margin (Group 2, n = 32) were included in the study. RP specimens were re‐evaluated for the presence of IDC‐P component and other prognostic factors. In both the groups, prognostic factors were compared according to the presence of IDC‐P and biochemical recurrence status. Results In Group 1, IDC‐P was detected in five cases and biochemical recurrence was detected in three cases. Patients with IDC‐P showed significantly higher biochemical recurrence than those without IDC‐P (P = .002). In univariate analysis, IDC‐P was found to be significantly associated with worse progression‐free survival (P