Right ventricular strain in Anderson-Fabry disease

2D speckle tracking echocardiography (2DSTE) is superior to standard echocardiography in the assessment of subtle right ventricle (RV) systolic dysfunction. In this study we aimed to: 1) test the hypothesis that 2DSTE may unveil subtle RV systolic dysfunction in patients with Fabry disease; 2) inves...

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Veröffentlicht in:International journal of cardiology 2021-05, Vol.330, p.84-90
Hauptverfasser: Lillo, Rosa, Graziani, Francesca, Panaioli, Elena, Mencarelli, Erica, Pieroni, Maurizio, Camporeale, Antonia, Manna, Raffaele, Sicignano, Ludovico Luca, Verrecchia, Elena, Lombardo, Antonella, Lanza, Gaetano Antonio, Crea, Filippo
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Sprache:eng
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Zusammenfassung:2D speckle tracking echocardiography (2DSTE) is superior to standard echocardiography in the assessment of subtle right ventricle (RV) systolic dysfunction. In this study we aimed to: 1) test the hypothesis that 2DSTE may unveil subtle RV systolic dysfunction in patients with Fabry disease; 2) investigate whether the physiologic difference between the 3-segment (RV-FWS) and the 6-segment (RV-GLS) RV strain (∆RV strain) is preserved in Fabry patients. Standard echocardiography and 2DSTE were performed in 49 Fabry patients and 49 age- and sex-matched healthy controls. Fabry patients were divided in two groups according to the presence/absence of left ventricular hypertrophy (LVH+: left ventricular wall thickness > 12 mm, 49% of total Fabry patients). RV systolic function assessed by standard echocardiography was normal in the majority of Fabry patients (92%) while RV-GLS and RV-FWS were impaired in about 40%. RV-GLS and RV-FWS were significantly worse in patients LVH+ vs LVH- and vs controls (RV-GLS: LVH+ vs LVH-: −18.4 ± −4.3% vs −23.8 ± −3.1% p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2021.02.038