Neuronal plumes initiate spreading depolarization, the electrophysiologic event driving migraine and stroke

Neuronal plumes initiate spreading depolarization, the electrophysiologic event driving migraine and stroke

In this issue of Neuron, Parker et al. discover neuronal plumes of glutamate release that initiate spreading depolarization, the electrophysiologic event underlying migraine. Mice with human migraine mutations express spontaneous and frequent plumes, which may explain the propensity to develop migra...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2021-02, Vol.109 (4), p.563-565
1. Verfasser: Eikermann-Haerter, Katharina
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cortical Spreading Depression
Depolarization
Glutamates
Headache
Homeostasis
Ischemia
Metabolism
Mice
Migraine
Migraine Disorders
Migraine with Aura
Models, Genetic
Mutation
Neurological disorders
Neurons
Pathophysiology
Patients
Plumes
Spreading depression
Stroke
Traumatic brain injury
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Zusammenfassung:In this issue of Neuron, Parker et al. discover neuronal plumes of glutamate release that initiate spreading depolarization, the electrophysiologic event underlying migraine. Mice with human migraine mutations express spontaneous and frequent plumes, which may explain the propensity to develop migraine attacks and the increased stroke risk in migraine-susceptible brains.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2021.01.024