Design, synthesis and anti-rheumatoid arthritis evaluation of double-ring conjugated enones
[Display omitted] •Four series of double-ring conjugated enones were designed and synthesized for inhibit synovial cell activity.•All compounds were in vitro evaluated for their rats synovial cells inhibitory activity.•Compound 151 and 168 showed a good inhibitory activities, with IC50 values of 2.7...
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Veröffentlicht in: | Bioorganic chemistry 2021-04, Vol.109, p.104701-104701, Article 104701 |
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Format: | Artikel |
Sprache: | eng |
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