Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

The recent paper by Pfeil et al., “Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs”, opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.

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Veröffentlicht in:Cell calcium (Edinburgh) 2021-03, Vol.94, p.102340-102340, Article 102340
Hauptverfasser: Wilkie, Thomas M., Hale, Michael A., Reddy, Sarthak
Format: Artikel
Sprache:eng
Schlagworte:
Calcium - metabolism
Calcium Signaling
Gi signaling
Gq signaling
GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism
Phospholipase C beta - metabolism
RGS proteins
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Zusammenfassung:The recent paper by Pfeil et al., “Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs”, opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2020.102340