Liver choline metabolism and gene expression in choline-deficient mice offspring differ with gender

Liver choline metabolism and gene expression in choline-deficient mice offspring differ with gender

Choline is an important nutrient during pregnancy and lactation. Maternal choline deficiency in CD-1 mice lowers liver betaine levels in male offspring. By contrast, it increases elovl3 and vanin-1 mRNA levels in female offspring. Taken together, these observations suggest gender-specific responses...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2021-02, Vol.85 (2), p.447-451
Hauptverfasser: Miyachi, Yukino, Akiyama, Kei, Tsukuda, Yoshiko, Kumrungsee, Thanutchaporn, Yanaka, Noriyuki
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Choline is an important nutrient during pregnancy and lactation. Maternal choline deficiency in CD-1 mice lowers liver betaine levels in male offspring. By contrast, it increases elovl3 and vanin-1 mRNA levels in female offspring. Taken together, these observations suggest gender-specific responses to a choline-deficient diet.
ISSN:1347-6947
1347-6947
DOI:10.1093/bbb/zbaa047