The plié by DNA-PK: dancing on DNA

In this issue of Molecular Cell, Chen et al. (2020) report the structural transition during DNA-dependent activation of DNA-PK, shedding light on the mechanism by which kinase inhibitors and auto-phosphorylation-deficient DNA-PKcs compromise non-homologous end-joining (Chen et al., 2020).

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell 2021-02, Vol.81 (4), p.644-646
Hauptverfasser:	Zha, Shan, Shao, Zhengping, Zhu, Yimeng
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - genetics DNA End-Joining Repair DNA-Activated Protein Kinase - genetics DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - metabolism Ku Autoantigen - metabolism Nuclear Proteins - metabolism Phosphorylation
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Beschreibung
Zusammenfassung:	In this issue of Molecular Cell, Chen et al. (2020) report the structural transition during DNA-dependent activation of DNA-PK, shedding light on the mechanism by which kinase inhibitors and auto-phosphorylation-deficient DNA-PKcs compromise non-homologous end-joining (Chen et al., 2020).
ISSN:	1097-2765 1097-4164
DOI:	10.1016/j.molcel.2021.01.025