Urinary Exosomal microRNA-21 as a Marker for Scrub Typhus-Associated Acute Kidney Injury

Urinary Exosomal microRNA-21 as a Marker for Scrub Typhus-Associated Acute Kidney Injury

Urinary microRNA (miRNA)-21 is a biomarker for acute kidney injury (AKI). We conducted this study to determine if a urinary exosomal analysis for this biomarker could serve as a novel diagnostic approach for detecting kidney disease. We investigated the clinical significance of urinary exosomal miRN...

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Veröffentlicht in:Genetic testing and molecular biomarkers 2021-02, Vol.25 (2), p.140-144
Hauptverfasser: Yun, Chi Young, Lim, Ji Hye, Oh, Ju Hwan, Cho, A Young, Lee, Kwang Young, Sun, In O
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Diagnosis
Glomerular filtration rate
Kidney diseases
Kidneys
Leukocytes
MicroRNAs
miRNA
Orientia tsutsugamushi
Ribonucleic acid
RNA
Scrub typhus
Typhus
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Zusammenfassung:Urinary microRNA (miRNA)-21 is a biomarker for acute kidney injury (AKI). We conducted this study to determine if a urinary exosomal analysis for this biomarker could serve as a novel diagnostic approach for detecting kidney disease. We investigated the clinical significance of urinary exosomal miRNA-21 levels for AKI in scrub typhus patients. We collected 138 urine samples from scrub typhus patients at the time of admission. Urinary exosomal miRNA-21 was assessed in 25 age- and sex-matched scrub typhus patients with and without AKI. The total leukocyte count was higher in AKI patients than in non-AKI patients (10.40 × 10 /mL vs. 6.40 × 10 /mL,  
ISSN:1945-0265
1945-0257
DOI:10.1089/gtmb.2020.0238