Oocyte ability to repair sperm DNA fragmentation: the impact of maternal age on intracytoplasmic sperm injection outcomes

To study the impact of sperm DNA fragmentation (SDF) on clinical outcomes of assisted reproductive technology in women with different age ranges. Historical cohort study. Private university–affiliated in vitro fertilization center. Five hundred forty couples undergoing intracytoplasmic sperm injection cycles. Cycles were split into three groups according to maternal age: ≤36 years old (n = 285), 37–40 years old (n = 147), and >40 years old (n = 108). Semen samples were evaluated for SDF using the Sperm Chromatin Dispersion test and, for each age group, the cycles were subdivided according to SDF index: low fragmentation index (