The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995–2040

The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995–2040

Background NAFLD is increasing in Asia including Japan, despite its lower obesity rate than the West. However, NAFLD can occur in lean people, but data are limited. We aimed to investigate the epidemiology of NAFLD in Japan with a focus on lean NAFLD. Methods We searched PubMed, Cochrane Library, EM...

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Veröffentlicht in:Hepatology international 2021-04, Vol.15 (2), p.366-379
Hauptverfasser: Ito, Takanori, Ishigami, Masatoshi, Zou, Biyao, Tanaka, Taku, Takahashi, Hirokazu, Kurosaki, Masayuki, Maeda, Mayumi, Thin, Khin Naing, Tanaka, Kenichi, Takahashi, Yuka, Itoh, Yoshito, Oniki, Kentaro, Seko, Yuya, Saruwatari, Junji, Kawanaka, Miwa, Atsukawa, Masanori, Hyogo, Hideyuki, Ono, Masafumi, Ogawa, Eiichi, Barnett, Scott D., Stave, Christopher D., Cheung, Ramsey C., Fujishiro, Mitsuhiro, Eguchi, Yuichiro, Toyoda, Hidenori, Nguyen, Mindie H.
Format: Artikel
Sprache:eng
Schlagworte:
Bayesian analysis
Colorectal Surgery
Diabetes mellitus
Epidemiology
Forecasting
Hepatology
Liver cancer
Mathematical models
Medical prognosis
Medicine
Medicine & Public Health
Meta-analysis
Metabolic syndrome
Mortality
Original Article
Surgery
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Zusammenfassung:Background NAFLD is increasing in Asia including Japan, despite its lower obesity rate than the West. However, NAFLD can occur in lean people, but data are limited. We aimed to investigate the epidemiology of NAFLD in Japan with a focus on lean NAFLD. Methods We searched PubMed, Cochrane Library, EMBASE, Web of Science, and the Japan Medical Abstracts Society (inception to 5/15/2019) and included 73 eligible full-text original research studies ( n  = 258,531). We used random-effects model for pooled estimates, Bayesian modeling for trend and forecasting, contacted authors for individual patient data and analyzed 14,887 (7752 NAFLD; 7135 non-NAFLD—8 studies) patients. Results The overall NAFLD prevalence was 25.5%, higher in males ( p  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-021-10143-4