Synthesis of Substituted Benzo[b]thiophenes via Base-Promoted Domino Condensation–Intramolecular C–S Bond Formation

Synthesis of Substituted Benzo[b]thiophenes via Base-Promoted Domino Condensation–Intramolecular C–S Bond Formation

A novel synthesis of 2,3-substituted benzothiophenes is reported, involving a tandem base-mediated condensation of o-iodoarylacetonitriles/acetates/ketones with (hetero)­aryldithioesters and an intramolecular C–S bond formation. The reaction affords diversely substituted benzothiophenes and heterofu...

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Veröffentlicht in:Organic letters 2021-03, Vol.23 (5), p.1698-1702
Hauptverfasser: Kumar, Yogendra, Ila, Hiriyakkanavar
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel synthesis of 2,3-substituted benzothiophenes is reported, involving a tandem base-mediated condensation of o-iodoarylacetonitriles/acetates/ketones with (hetero)­aryldithioesters and an intramolecular C–S bond formation. The reaction affords diversely substituted benzothiophenes and heterofused thiophenes in excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c00085