Purification, identification, and computational analysis of xanthine oxidase inhibitory peptides from kidney bean

Purification, identification, and computational analysis of xanthine oxidase inhibitory peptides from kidney bean

Hyperuricemia is related to plenty of diseases, seriously damaging human health. Current clinical drugs used to treat hyperuricemia have many adverse effects. In this study, kidney bean hydrolysate (KBH) was found to exert high xanthine oxidase inhibitory (XOI) activity. Compared to KBH (50.31 ± 2.7...

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Veröffentlicht in:Journal of food science 2021-03, Vol.86 (3), p.1081-1088
Hauptverfasser: Wu, Yuqun, He, Hui, Hou, Tao
Format: Artikel
Sprache:eng
Schlagworte:
Affinity
Amino acids
Beans
Binding
Computer applications
Drugs
Functional foods & nutraceuticals
High-performance liquid chromatography
Hydrogen bonding
Hydrogen bonds
Hydrolysates
Hydrophobicity
Hyperuricemia
identification
kidney bean hydrolysate (KBH)
Kidney beans
Liquid chromatography
Molecular docking
Peptides
Phaseolus vulgaris
Protein purification
Side effects
Synthetic peptides
Ultrafiltration
Vegetables
Xanthine oxidase
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Zusammenfassung:Hyperuricemia is related to plenty of diseases, seriously damaging human health. Current clinical drugs used to treat hyperuricemia have many adverse effects. In this study, kidney bean hydrolysate (KBH) was found to exert high xanthine oxidase inhibitory (XOI) activity. Compared to KBH (50.31 ± 2.73%), XOI activities of three fractions (Mw
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.15603