Palladium-Catalyzed Dual Coupling Reaction of 2‑Iodobiphenyls with o‑Bromoanilines through C–H Activation: An Approach for the Synthesis of Tribenzo[b,d,f]azepines

Palladium-Catalyzed Dual Coupling Reaction of 2‑Iodobiphenyls with o‑Bromoanilines through C–H Activation: An Approach for the Synthesis of Tribenzo[b,d,f]azepines

A novel and straightforward approach for the synthesis of tribenzo­[b,d,f]­azepines starting from 2-iodobiphenyls and 2-bromoanilines has been developed. A wide range of tribenzo­[b,d,f]­azepines were obtained in good to excellent yields via a cascade intermolecular palladium-catalyzed C–H activatio...

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Veröffentlicht in:Organic letters 2021-02, Vol.23 (4), p.1239-1242
Hauptverfasser: Cheng, Cang, Tu, Dongdong, Zuo, Xiang, Wu, Zechen, Wan, Bin, Zhang, Yanghui
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container_issue 4
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container_title Organic letters
container_volume 23
creator Cheng, Cang
Tu, Dongdong
Zuo, Xiang
Wu, Zechen
Wan, Bin
Zhang, Yanghui
description A novel and straightforward approach for the synthesis of tribenzo­[b,d,f]­azepines starting from 2-iodobiphenyls and 2-bromoanilines has been developed. A wide range of tribenzo­[b,d,f]­azepines were obtained in good to excellent yields via a cascade intermolecular palladium-catalyzed C–H activation/dual coupling reaction. C,C-palladacycles, which are generated by C–H activation of 2-iodobiphenyls, should be the reaction intermediates.
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title Palladium-Catalyzed Dual Coupling Reaction of 2‑Iodobiphenyls with o‑Bromoanilines through C–H Activation: An Approach for the Synthesis of Tribenzo[b,d,f]azepines
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