Synthesis of novel potent cytotoxicy podophyllotoxin-naphthoquinone compounds via microwave-assited multicomponent domino reactions

[Display omitted] •Sixteen new podophyllotoxin analogs containing naphthoquinone moiety on B ring 5a-p were designed and synthesized.•The plausible mechanism for formation of compounds 5a-p was described.•Their anticancer activities against KB, HepG2, SK-Lu-1, and MCF7 cancer cell lines were evaluat...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2021-04, Vol.37, p.127841-127841, Article 127841
Hauptverfasser: Nguyen Thi, Quynh Giang, Le-Nhat-Thuy, Giang, Dang Thi, Tuyet Anh, Hoang Thi, Phuong, Nguyen Tuan, Anh, Nguyen Thi, Thu Ha, Nguyen, Thanh Tra, Nguyen Ha, Thanh, Hoang Mai, Ha, Nguyen, Tuyen Van
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Sprache:eng
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Zusammenfassung:[Display omitted] •Sixteen new podophyllotoxin analogs containing naphthoquinone moiety on B ring 5a-p were designed and synthesized.•The plausible mechanism for formation of compounds 5a-p was described.•Their anticancer activities against KB, HepG2, SK-Lu-1, and MCF7 cancer cell lines were evaluated.•Compound 5a, 5d, 5h and 5k were found to be the most promising cytotoxic agent against HepG2 and SK-Lu-1 with IC50 
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2021.127841