A survey of human histone H1 subtypes interaction networks: Implications for histones H1 functioning

To show a spectrum of histone H1 subtypes (H1.1‐H1.5) activity realized through the protein‐protein interactions, data selected from APID resources were processed with sequence‐based bioinformatics approaches. Histone H1 subtypes participate in over half a thousand interactions with nuclear and cyto...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2021-07, Vol.89 (7), p.792-810
1. Verfasser:	Kowalski, Andrzej
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Binding Binding Sites Bioinformatics Biological activity biological process Cell cycle Cell Cycle - genetics Cell division Cell Nucleus - genetics Cell Nucleus - metabolism Cellular communication Cytosol - metabolism Databases, Protein Enzymatic activity Eukaryotic Cells - cytology Eukaryotic Cells - metabolism Folding Gene Ontology Histone H1 histone H1 subtypes Histones Histones - chemistry Histones - classification Histones - genetics Histones - metabolism Hubs Humans intrinsic structural disorder Intrinsically Disordered Proteins - chemistry Intrinsically Disordered Proteins - classification Intrinsically Disordered Proteins - genetics Intrinsically Disordered Proteins - metabolism Kinetics Mitochondria - genetics Mitochondria - metabolism molecular function Molecular Sequence Annotation Multigene Family Networks Nucleic acids Protein Binding Protein Folding Protein interaction Protein Interaction Mapping Protein Isoforms - chemistry Protein Isoforms - classification Protein Isoforms - genetics Protein Isoforms - metabolism Proteins protein‐protein interaction networks Thermodynamics transient interactions Ubiquitination
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Zusammenfassung:	To show a spectrum of histone H1 subtypes (H1.1‐H1.5) activity realized through the protein‐protein interactions, data selected from APID resources were processed with sequence‐based bioinformatics approaches. Histone H1 subtypes participate in over half a thousand interactions with nuclear and cytosolic proteins (ComPPI database) engaged in the enzymatic activity and binding of nucleic acids and proteins (SIFTER tool). Small‐scale networks of H1 subtypes (STRING network) have similar topological parameters (P > .05) which are, however, different for networks hubs between subtype H1.1 and H1.4 and subtype H1.3 and H1.5 (P
ISSN:	0887-3585 1097-0134
DOI:	10.1002/prot.26059