Acquired haemophilia A in the postpartum and risk of relapse in subsequent pregnancies: A systematic literature review

Acquired haemophilia A in the postpartum and risk of relapse in subsequent pregnancies: A systematic literature review

Background About 1%–5% of acquired haemophilia A cases affect mothers in the postpartum setting. Aims This study delineates the characteristics of this disease, specific to the postpartum setting, notably relapse in subsequent pregnancies. Methods Report of two cases and literature study (1946–2019)...

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Veröffentlicht in:Haemophilia : the official journal of the World Federation of Hemophilia 2021-03, Vol.27 (2), p.199-210
Hauptverfasser: Dewarrat, Natacha, Gavillet, Mathilde, Angelillo‐Scherrer, Anne, Naveiras, Olaia, Grandoni, Francesco, Tsakiris, Dimitrios A., Alberio, Lorenzo, Blum, Sabine
Format: Artikel
Sprache:eng
Schlagworte:
acquired
Diagnosis
Factor VIII deficiency
Haemophilia A
Hemophilia
Immunosuppressive agents
Literature reviews
Patients
Postpartum
postpartum haemorrhage
postpartum period
Pregnancy
recurrence
Rituximab
Steroid hormones
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Zusammenfassung:Background About 1%–5% of acquired haemophilia A cases affect mothers in the postpartum setting. Aims This study delineates the characteristics of this disease, specific to the postpartum setting, notably relapse in subsequent pregnancies. Methods Report of two cases and literature study (1946–2019), yielding 73 articles describing 174 cases (total 176 cases). Results Patients were aged 29.9 years (17–41) and 69% primigravidae. Diagnosis was made at a median of 60 days after delivery (range 0–308). Bleeding types were obstetrical (43.4%), cutaneous (41.3%), and muscular (36.7%). In >90% of the cases, FVIII at diagnosis was
ISSN:1351-8216
1365-2516
DOI:10.1111/hae.14233