Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease

Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease

DNA damage and alterations in DNA damage response (DDR) signaling could be one of the molecular mechanisms mediating focal kidney cyst formation in autosomal dominant polycystic kidney disease (ADPKD). The aim of this study was to test the hypothesis that markers of DNA damage and DDR signaling are...

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Veröffentlicht in:The American journal of pathology 2021-05, Vol.191 (5), p.902-920
Hauptverfasser: Zhang, Jennifer Q.J., Saravanabavan, Sayanthooran, Chandra, Ashley N., Munt, Alexandra, Wong, Annette T.Y., Harris, Peter C., Harris, David C.H., McKenzie, Paul, Wang, Yiping, Rangan, Gopala K.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Line
Cysts - pathology
DNA Damage
Dogs
Epithelial Cells - pathology
Female
Humans
Hydrogen Peroxide - metabolism
Kidney - pathology
Male
Mice
Mice, Inbred C57BL
Mutation
Phosphorylation
Polycystic Kidney, Autosomal Dominant - genetics
Polycystic Kidney, Autosomal Dominant - pathology
Signal Transduction
Up-Regulation
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Zusammenfassung:DNA damage and alterations in DNA damage response (DDR) signaling could be one of the molecular mechanisms mediating focal kidney cyst formation in autosomal dominant polycystic kidney disease (ADPKD). The aim of this study was to test the hypothesis that markers of DNA damage and DDR signaling are increased in human and experimental ADPKD. In the human ADPKD transcriptome, the number of up-regulated DDR-related genes was increased by 16.6-fold compared with that in normal kidney, and by 2.5-fold in cystic compared with that in minimally cystic tissue (P 
ISSN:0002-9440
1525-2191
DOI:10.1016/j.ajpath.2021.01.011