The role of microglia in chronic pain and depression: innocent bystander or culprit?

The role of microglia in chronic pain and depression: innocent bystander or culprit?

Clinical evidence shows that chronic pain and depression often accompany each other, but the underlying pathogenesis of comorbid chronic pain and depression remains mostly undetermined. Biotechnology is gradually revealing the phenotype and function of microglia, with great progress regarding microg...

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Veröffentlicht in:Psychopharmacology 2021-04, Vol.238 (4), p.949-958
Hauptverfasser: Yin, Nan, Yan, Enshi, Duan, Wenbin, Mao, Changyuan, Fei, Qin, Yang, Chun, Hu, Yimin, Xu, Xiaolin
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Biotechnology
Chronic pain
Chronic Pain - physiopathology
Comorbidity
Depression - physiopathology
Depression, Mental
Diagnosis
Humans
Mental depression
Microglia
Neurodegeneration
Neurosciences
Pain
Pharmacology/Toxicology
Phenotypes
Psychiatry
Review
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Zusammenfassung:Clinical evidence shows that chronic pain and depression often accompany each other, but the underlying pathogenesis of comorbid chronic pain and depression remains mostly undetermined. Biotechnology is gradually revealing the phenotype and function of microglia, with great progress regarding microglia’s role in neurodegeneration, depression, chronic pain, and other conditions. This article summarizes the role of microglia in chronic pain, depression, and comorbidities, which is conducive to finding new targets to treat chronic pain and depression.
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-021-05780-4