Direct Access to Primary Amines from Alkenes by Selective Metal‐Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal‐free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α‐branched, and α‐tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas. A straightforward and modular route to a wide variety of aliphatic primary amines from alkenes is presented based on a metal‐free hydroamination at room temperature. The use of cost‐effective and easily available ammonium carbonate allows for the efficient conversion of terminal and internal alkenes with diverse substitution patterns into highly functionalized linear, α‐branched, and α‐tertiary primary amines.