Asymmetric syntheses of spiro[benzofuro-cyclopenta[1,2-b]indole-indoline] scaffolds via consecutive cyclization

Asymmetric syntheses of spiro[benzofuro-cyclopenta[1,2-b]indole-indoline] scaffolds via consecutive cyclization

An efficient method to construct enantioenriched spiro[benzofuro-cyclopenta[1,2-b]indole-indoline] scaffolds via consecutive cyclization is described here. The new scaffolds possess five successive chiral stereogenic centers and two spiroheterocycles. A range of highly enantioenriched scaffolds has...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-03, Vol.57 (18), p.2313-2316
Hauptverfasser: Zhang, Heng, Guan, Xu-Kai, Sun, Dong-Yang, Liu, Guo-Feng, Gao, Ji-Gang, Zhang, Guang-Liang, Zhang, Suo-Qin
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography
Scaffolds
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Zusammenfassung:An efficient method to construct enantioenriched spiro[benzofuro-cyclopenta[1,2-b]indole-indoline] scaffolds via consecutive cyclization is described here. The new scaffolds possess five successive chiral stereogenic centers and two spiroheterocycles. A range of highly enantioenriched scaffolds has been obtained with up to 93% yield, 99% ee and >19 : 1 d.r. catalyzed by Brønsted acid catalysts.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc08083g