Investigating the possible association between NLRP3 gene polymorphisms and myasthenia gravis

Introduction In this case‐control study, we investigated the association between nucleotide oligomerization domain‐like receptor family pyrin domain containing 3 (NLRP3) single‐nucleotide polymorphisms (SNPs) rs10754558, rs3806265, rs4612666, and rs35829419 and myasthenia gravis (MG). Methods Samples from MG patients were selected from a previous study conducted in our neuromuscular clinic, which investigated the association between human leukocyte antigen (HLA) class II genes and MG. Genetic data of controls were also available from another study. The NLRP3 SNPs genotyping was performed using the TaqMan method. Results A total of 93 blood samples from eligible Iranian patients with MG and 56 samples from healthy controls were obtained. The NLRP3 rs3806265 “C” allele was significantly more frequent in MG patients (P