Serologic and molecular studies to identify neonatal alloimmune neutropenia in a cohort of 10,000 neonates

Serologic and molecular studies to identify neonatal alloimmune neutropenia in a cohort of 10,000 neonates

Summary Neonatal alloimmune neutropenia (NAIN) is caused by maternal alloimmunisation to fetal human neutrophil antigens (HNAs). This study investigated maternal HNA/HLA alloantibodies involved with NAIN and identified the frequency of NAIN in Brazilian neonates. Neonatal neutropenia (neutrophil cou...

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Veröffentlicht in:British journal of haematology 2021-02, Vol.192 (4), p.778-784
Hauptverfasser: Abbas, Samira A., Lopes, Larissa B., Moritz, Elyse, Martins, Juliana O., Chiba, Akemi K, Kunioshi, Alessandra M., Barbosa, Elisama S., Langhi Junior, Dante M., Santos, Amélia M. N., Godinho, Cárlei H., Bordin, José O.
Format: Artikel
Sprache:eng
Schlagworte:
Agglutination
Alloantibodies
Antibodies
Antigens
Anti‐HNA‐1d
Anti‐HNA‐3b
Fetuses
Genotyping
Hematology
Histocompatibility antigen HLA
Immunofluorescence
Investigations
Leukocytes (granulocytic)
Leukocytes (neutrophilic)
maternal‐fetal HNA incompatibility
neonatal alloimmune neutropenia
Neonates
Neutropenia
neutrophil alloimmunisation
Neutrophils
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Zusammenfassung:Summary Neonatal alloimmune neutropenia (NAIN) is caused by maternal alloimmunisation to fetal human neutrophil antigens (HNAs). This study investigated maternal HNA/HLA alloantibodies involved with NAIN and identified the frequency of NAIN in Brazilian neonates. Neonatal neutropenia (neutrophil count 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.17295