Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy
Abstract Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and indu...
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| Veröffentlicht in: | Clinical infectious diseases 2021-02, Vol.72 (3), p.495-498 |
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| creator | Papasavvas, Emmanouil Azzoni, Livio Ross, Brian N Fair, Matthew Yuan, Zhe Gyampoh, Kwasi Mackiewicz, Agnieszka Sciorillo, Amanda C Pagliuzza, Amelie Lada, Steven M Wu, Guoxin Goh, Shih Lin Bahnck-Teets, Carolyn Holder, Daniel J Zuck, Paul D Damra, Mohammad Lynn, Kenneth M Tebas, Pablo Mounzer, Karam Kostman, Jay R Abdel-Mohsen, Mohamed Richman, Douglas Chomont, Nicolas Howell, Bonnie J Montaner, Luis J |
| description | Abstract
Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV. |
| doi_str_mv | 10.1093/cid/ciaa809 |
| format | Article |
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Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciaa809</identifier><identifier>PMID: 33527127</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>CD4-Positive T-Lymphocytes ; DNA, Viral - genetics ; HIV Infections - drug therapy ; HIV-1 - genetics ; Humans ; Proviruses - genetics ; Virus Latency</subject><ispartof>Clinical infectious diseases, 2021-02, Vol.72 (3), p.495-498</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e5e4ff62abf02fa145f3fa7d0b76a37ca88249fce129be96a3067821628152023</citedby><cites>FETCH-LOGICAL-c357t-e5e4ff62abf02fa145f3fa7d0b76a37ca88249fce129be96a3067821628152023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33527127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papasavvas, Emmanouil</creatorcontrib><creatorcontrib>Azzoni, Livio</creatorcontrib><creatorcontrib>Ross, Brian N</creatorcontrib><creatorcontrib>Fair, Matthew</creatorcontrib><creatorcontrib>Yuan, Zhe</creatorcontrib><creatorcontrib>Gyampoh, Kwasi</creatorcontrib><creatorcontrib>Mackiewicz, Agnieszka</creatorcontrib><creatorcontrib>Sciorillo, Amanda C</creatorcontrib><creatorcontrib>Pagliuzza, Amelie</creatorcontrib><creatorcontrib>Lada, Steven M</creatorcontrib><creatorcontrib>Wu, Guoxin</creatorcontrib><creatorcontrib>Goh, Shih Lin</creatorcontrib><creatorcontrib>Bahnck-Teets, Carolyn</creatorcontrib><creatorcontrib>Holder, Daniel J</creatorcontrib><creatorcontrib>Zuck, Paul D</creatorcontrib><creatorcontrib>Damra, Mohammad</creatorcontrib><creatorcontrib>Lynn, Kenneth M</creatorcontrib><creatorcontrib>Tebas, Pablo</creatorcontrib><creatorcontrib>Mounzer, Karam</creatorcontrib><creatorcontrib>Kostman, Jay R</creatorcontrib><creatorcontrib>Abdel-Mohsen, Mohamed</creatorcontrib><creatorcontrib>Richman, Douglas</creatorcontrib><creatorcontrib>Chomont, Nicolas</creatorcontrib><creatorcontrib>Howell, Bonnie J</creatorcontrib><creatorcontrib>Montaner, Luis J</creatorcontrib><title>Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.</description><subject>CD4-Positive T-Lymphocytes</subject><subject>DNA, Viral - genetics</subject><subject>HIV Infections - drug therapy</subject><subject>HIV-1 - genetics</subject><subject>Humans</subject><subject>Proviruses - genetics</subject><subject>Virus Latency</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EoqVw4o58QkVVwB9x4hyXpWVXWgGCpRwjxxl3jZI4tZ2V8g_5WXi7W44crLFGzzwjzYvQa0reU1LxD9q26SklSfUEnVPBy6wQFX2a_kTILJdcnqEXIfwmhFJJxHN0xrlgJWXlOfqzHqLSEa-mXg143ffT4FowVlsY9IxvrZ8Cvlytb9_h7xDA7531-DpE26sILW5mHHeAT5Jv3u2tVx3-9GWBFyGoGS-d99AlNuBfNu7wBvbQBewM3rqYSDW0h2m48w--w6AdHpwfO-dSY_J2uMM_pnH0EILdA14M0XqIj7u2O_BqnF-iZ0Z1AV6d6gX6eXO9Xa6yzdfP6-Vik2kuypiBgNyYgqnGEGYUzYXhRpUtacpC8VIrKVleGQ2UVQ1UqUeKUjJaMEkFI4xfoMujd_TufoIQ694GDV2nBnBTqFkuRQJTAAm9OqLauxA8mHr06W5-rimpD9HVKbr6FF2i35zEU9ND-499zCoBb4-Am8b_mv4CSrOlJg</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Papasavvas, Emmanouil</creator><creator>Azzoni, Livio</creator><creator>Ross, Brian N</creator><creator>Fair, Matthew</creator><creator>Yuan, Zhe</creator><creator>Gyampoh, Kwasi</creator><creator>Mackiewicz, Agnieszka</creator><creator>Sciorillo, Amanda C</creator><creator>Pagliuzza, Amelie</creator><creator>Lada, Steven M</creator><creator>Wu, Guoxin</creator><creator>Goh, Shih Lin</creator><creator>Bahnck-Teets, Carolyn</creator><creator>Holder, Daniel J</creator><creator>Zuck, Paul D</creator><creator>Damra, Mohammad</creator><creator>Lynn, Kenneth M</creator><creator>Tebas, Pablo</creator><creator>Mounzer, Karam</creator><creator>Kostman, Jay R</creator><creator>Abdel-Mohsen, Mohamed</creator><creator>Richman, Douglas</creator><creator>Chomont, Nicolas</creator><creator>Howell, Bonnie J</creator><creator>Montaner, Luis J</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210201</creationdate><title>Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy</title><author>Papasavvas, Emmanouil ; 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Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33527127</pmid><doi>10.1093/cid/ciaa809</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2021-02, Vol.72 (3), p.495-498 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | CD4-Positive T-Lymphocytes DNA, Viral - genetics HIV Infections - drug therapy HIV-1 - genetics Humans Proviruses - genetics Virus Latency |
| title | Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy |
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