Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy

Abstract Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and indu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical infectious diseases 2021-02, Vol.72 (3), p.495-498
Hauptverfasser:	Papasavvas, Emmanouil, Azzoni, Livio, Ross, Brian N, Fair, Matthew, Yuan, Zhe, Gyampoh, Kwasi, Mackiewicz, Agnieszka, Sciorillo, Amanda C, Pagliuzza, Amelie, Lada, Steven M, Wu, Guoxin, Goh, Shih Lin, Bahnck-Teets, Carolyn, Holder, Daniel J, Zuck, Paul D, Damra, Mohammad, Lynn, Kenneth M, Tebas, Pablo, Mounzer, Karam, Kostman, Jay R, Abdel-Mohsen, Mohamed, Richman, Douglas, Chomont, Nicolas, Howell, Bonnie J, Montaner, Luis J
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes DNA, Viral - genetics HIV Infections - drug therapy HIV-1 - genetics Humans Proviruses - genetics Virus Latency
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciaa809