New solution of beauty problem by Staphylococcus hominis: Relevance between skin microbiome and skin condition in healthy subject

Background/aims Recently, it was suggested that skin microbiome is related to some skin disease. The possibility of affecting the skin might be high, but there were few reports of the influence on the skin condition in healthy subjects. Our aim was to evaluate the relationship between skin condition and skin microbiome in healthy subjects. Methods Experiment 1: 293 Japanese healthy women were divided into two groups, good skin properties and poor skin properties by 14 skin physiology parameter values on the cheek using noninvasive method. Differences of abundance of bacterial species on the cheek between the two groups were evaluated. Experiment 2: 11 Japanese healthy women were applied Staphylococcus hominis (S. hominis) on half‐side of cheek for eight times in 1 month. Difference of change of physiology parameter values comparing to placebo side was evaluated. Results Experiment 1: Multiple skin bacterial species were found to be significantly relevant in 14 physiology parameters. The abundance of S. hominis on the cheek with good skin properties group was significantly higher than poor skin properties group. Experiment 2: The application of S. hominis improved significantly the conspicuous pore number, melanin index, and the wrinkle count compared to placebo side. Conclusion We found many skin bacterial species that might improve the skin condition in healthy women. In particular, S. hominis might have the potential to improve multiple skin beauty problems.