Effect of Glomerular Filtration Rates on Outcomes Following Percutaneous Left Atrial Appendage Closure

Scarce data support the prescription of oral anticoagulation in patients with concomitant advanced chronic kidney disease (CKD) and atrial fibrillation, and left atrial appendage closure (LAAC) may provide a favorable risk-benefit ratio in this population. However, outcomes of LAAC in CKD patients a...

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Veröffentlicht in:	The American journal of cardiology 2021-04, Vol.145, p.77-84
Hauptverfasser:	Faroux, Laurent, Cruz-González, Ignacio, Arzamendi, Dabit, Freixa, Xavier, Nombela-Franco, Luis, Peral, Vicente, Caneiro-Queija, Berenice, Mangieri, Antonio, Trejo-Velasco, Blanca, Asmarats, Lluis, Regueiro, Ander, McInerney, Angela, Mas-Lladó, Caterina, Estevez-Loureiro, Rodrigo, Laricchia, Alessandra, O'Hara, Gilles, Rodés-Cabau, Josep
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Aged Aged, 80 and over Anticoagulants Anticoagulants - therapeutic use Atrial Appendage - surgery Atrial Fibrillation - complications Atrial Fibrillation - epidemiology Atrial Fibrillation - surgery Bleeding Cardiac Surgical Procedures Cardiac Tamponade - epidemiology Comorbidity Complications Confidence intervals Death Embolism - etiology Embolism - prevention & control Embolisms Epidermal growth factor receptors Esophagus Female Fibrillation General anesthesia Glomerular Filtration Rate Health risks Hemodialysis Humans Hypertension Ischemia Ischemic Attack, Transient - etiology Ischemic Attack, Transient - prevention & control Ischemic Stroke - etiology Ischemic Stroke - prevention & control Kidney diseases Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - therapy Kidneys Male Mortality Patients Platelet Aggregation Inhibitors - therapeutic use Postoperative Complications - epidemiology Postoperative Hemorrhage - epidemiology Renal Dialysis Renal Insufficiency, Chronic - epidemiology Risk Severity of Illness Index Stroke Stroke - epidemiology Thromboembolism Thrombosis
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Zusammenfassung:	Scarce data support the prescription of oral anticoagulation in patients with concomitant advanced chronic kidney disease (CKD) and atrial fibrillation, and left atrial appendage closure (LAAC) may provide a favorable risk-benefit ratio in this population. However, outcomes of LAAC in CKD patients are unknown. We aimed to investigate the impact of moderate-to-severe CKD on clinical outcomes following percutaneous LAAC. This was a multicenter study including 1094 patients who underwent LAAC. Moderate-to-severe CKD was defined as an eGFR
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2020.12.081