New Insights into the Role of Ferritin in Iron Homeostasis and Neurodegenerative Diseases
Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an importa...
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| Veröffentlicht in: | Molecular neurobiology 2021-06, Vol.58 (6), p.2812-2823 |
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| creator | Zhang, Na Yu, Xiaoqi Xie, Junxia Xu, Huamin |
| description | Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintaining iron homeostasis. Recently, the discovery of extracellular ferritin and ferritin in exosomes indicates that ferritin might be not only an iron storage protein within the cell, but might also be an important factor in the regulation of tissue and body iron homeostasis. In this review, we first described the structural characteristics, regulation and the physiological functions of ferritin. Secondly, we reviewed the current evidence concerning the mechanisms underlying the secretion of ferritin and the possible role of secreted ferritin in the brain. Then, we summarized the relationship between ferritin and the neurodegenerative diseases including Parkinson’s disease (PD), Alzheimer’s disease (AD) and neuroferritinopathy (NF). Given the importance and relationship between iron and neurodegenerative diseases, understanding the role of ferritin in the brain can be expected to contribute to our knowledge of iron dysfunction and neurodegenerative diseases. |
| doi_str_mv | 10.1007/s12035-020-02277-7 |
| format | Article |
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Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintaining iron homeostasis. Recently, the discovery of extracellular ferritin and ferritin in exosomes indicates that ferritin might be not only an iron storage protein within the cell, but might also be an important factor in the regulation of tissue and body iron homeostasis. In this review, we first described the structural characteristics, regulation and the physiological functions of ferritin. Secondly, we reviewed the current evidence concerning the mechanisms underlying the secretion of ferritin and the possible role of secreted ferritin in the brain. Then, we summarized the relationship between ferritin and the neurodegenerative diseases including Parkinson’s disease (PD), Alzheimer’s disease (AD) and neuroferritinopathy (NF). Given the importance and relationship between iron and neurodegenerative diseases, understanding the role of ferritin in the brain can be expected to contribute to our knowledge of iron dysfunction and neurodegenerative diseases.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-020-02277-7</identifier><identifier>PMID: 33507490</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer's disease ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Exosomes ; Ferritin ; Homeostasis ; Iron ; Movement disorders ; Neurobiology ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Parkinson's disease</subject><ispartof>Molecular neurobiology, 2021-06, Vol.58 (6), p.2812-2823</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1d10dd8350b559bf64eda65db7d0d5cf075a47c66e04903cb08101f2f0be225f3</citedby><cites>FETCH-LOGICAL-c375t-1d10dd8350b559bf64eda65db7d0d5cf075a47c66e04903cb08101f2f0be225f3</cites><orcidid>0000-0002-1941-1956</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-020-02277-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-020-02277-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33507490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Na</creatorcontrib><creatorcontrib>Yu, Xiaoqi</creatorcontrib><creatorcontrib>Xie, Junxia</creatorcontrib><creatorcontrib>Xu, Huamin</creatorcontrib><title>New Insights into the Role of Ferritin in Iron Homeostasis and Neurodegenerative Diseases</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintaining iron homeostasis. Recently, the discovery of extracellular ferritin and ferritin in exosomes indicates that ferritin might be not only an iron storage protein within the cell, but might also be an important factor in the regulation of tissue and body iron homeostasis. In this review, we first described the structural characteristics, regulation and the physiological functions of ferritin. Secondly, we reviewed the current evidence concerning the mechanisms underlying the secretion of ferritin and the possible role of secreted ferritin in the brain. Then, we summarized the relationship between ferritin and the neurodegenerative diseases including Parkinson’s disease (PD), Alzheimer’s disease (AD) and neuroferritinopathy (NF). 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| source | SpringerNature Journals |
| subjects | Alzheimer's disease Biomedical and Life Sciences Biomedicine Cell Biology Exosomes Ferritin Homeostasis Iron Movement disorders Neurobiology Neurodegenerative diseases Neurology Neurosciences Parkinson's disease |
| title | New Insights into the Role of Ferritin in Iron Homeostasis and Neurodegenerative Diseases |
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