New-found brake calibrates insulin action in β-cells

Insulin is produced by pancreatic β-cells. The identification of a regulator of insulin signalling in these cells cements the long-standing idea that this pathway has a key role in β-cell biology. The protein inceptor restrains insulin signalling through endocytosis.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2021-02, Vol.590 (7845), p.221-223
1. Verfasser:	Kulkarni, Rohit N.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 692/699/2743/137 Beta cells Blood Glucose Diabetes Diabetes mellitus Gene expression Glucose Growth factors Humanities and Social Sciences Insulin Insulin - metabolism Insulin Secretion Insulin-like growth factor I Insulin-Secreting Cells - metabolism Metabolic pathways Metabolism Metabolites mRNA multidisciplinary News And Views Proteins Receptors Science Signal transduction
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Insulin is produced by pancreatic β-cells. The identification of a regulator of insulin signalling in these cells cements the long-standing idea that this pathway has a key role in β-cell biology. The protein inceptor restrains insulin signalling through endocytosis.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/d41586-021-00141-9