Visible-light promoted α-alkylation of glycine derivatives with alkyl boronic acids

A visible-light-mediated aerobic α-alkylation reaction of glycine derivatives with alkyl boronic acids has been established in the presence of a Ru/Cu catalyst system, giving the desired radical coupling products efficiently. The transformation features mild reaction conditions and broad substrate scope, delivering a wide range of complex unnatural α-amino-acid derivatives. A visible-light-mediated aerobic α-alkylation reaction of glycine derivatives with alkyl boronic acids has been established in the presence of a Ru/Cu catalyst system, giving the desired radical coupling products efficiently.