Brigham and Women's Hospital tumor classification system for basal cell carcinoma identifies patients with risk of metastasis and death

Despite approximately 4400 locally advanced US cases annually, high-stage basal cell carcinoma (BCC) is ill-defined. To develop a tumor (T) staging system for BCC that will predict metastasis/death and compare its performance with that of the American Joint Committee on Cancer 8th edition (AJCC8) T-...

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Veröffentlicht in:Journal of the American Academy of Dermatology 2021-09, Vol.85 (3), p.582-587
Hauptverfasser: Morgan, Frederick C., Ruiz, Emily Stamell, Karia, Pritesh S., Besaw, Robert J., Neel, Victor A., Schmults, Chrysalyne D.
Format: Artikel
Sprache:eng
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Zusammenfassung:Despite approximately 4400 locally advanced US cases annually, high-stage basal cell carcinoma (BCC) is ill-defined. To develop a tumor (T) staging system for BCC that will predict metastasis/death and compare its performance with that of the American Joint Committee on Cancer 8th edition (AJCC8) T-staging system. Brigham and Women's Hospital (BWH) T staging was developed from a previously published nested cohort of 488 primary BCCs. Tumors were staged via BWH and AJCC8 T-staging systems, and predictions of metastasis and/or death were compared. The BWH and AJCC8 T-staging systems both captured all metastases/deaths in high T stages (BWH, T2; AJCC8, T3/T4). BWH T2 included 54% fewer cases ≥2 cm than AJCC8 T3/T4. BWH had a higher specificity (0.92 vs 0.80; P 
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2021.01.052