Locally isolated broad host-range bacteriophage kills methicillin-resistant Staphylococcus aureus in an in vivo skin excisional wound model in mice

Locally isolated broad host-range bacteriophage kills methicillin-resistant Staphylococcus aureus in an in vivo skin excisional wound model in mice

From the perspective of an ever-increasing multidrug resistance among bacterial pathogens, bacteriophages are receiving renewed interest as potential alternative to antibiotics. We investigated the potential of a locally isolated species-specific phage against Staphylococcus aureus infection in a sk...

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Veröffentlicht in:Microbial pathogenesis 2021-03, Vol.152, p.104744-104744, Article 104744
Hauptverfasser: Shetru, Manjunath Nandihalli, Karched, Maribasappa, Agsar, Dayanand
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Bacteriophage therapy
Multidrug resistance
Skin infection
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Zusammenfassung:From the perspective of an ever-increasing multidrug resistance among bacterial pathogens, bacteriophages are receiving renewed interest as potential alternative to antibiotics. We investigated the potential of a locally isolated species-specific phage against Staphylococcus aureus infection in a skin excisional wound model in mice. A significant time-dependent increase (P 
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2021.104744