Antenatal corticosteroid therapy is associated with a lower risk of cystic periventricular leukomalacia

Antenatal corticosteroid therapy is associated with a lower risk of cystic periventricular leukomalacia

Aim To evaluate the association of antenatal corticosteroids (ACS) therapy on the risk for cystic periventricular leukomalacia (c‐PVL) in very low birth weight (VLBW), very preterm infants, whilst accounting for the occurrence of major neonatal morbidities; sepsis, necrotising enterocolitis, intrave...

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Veröffentlicht in:Acta Paediatrica 2021-06, Vol.110 (6), p.1795-1802
Hauptverfasser: Hershkovich Shporen, Calanit, Reichman, Brian, Zaslavsky‐Paltiel, Inna, Lerner‐Geva, Liat, Flidel‐Rimon, Orna
Format: Artikel
Sprache:eng
Schlagworte:
antenatal corticosteroids
Birth weight
bronchopulmonary dysplasia
Corticosteroids
cystic periventricular leukomalacia
Dysplasia
Enterocolitis
Gastrointestinal diseases
Hemorrhage
Infants
intraventricular haemorrhage
Low birth weight
Necrosis
necrotising enterocolitis
Necrotizing enterocolitis
neonatal morbidities
Neonates
Periventricular leukomalacia
Population studies
Sepsis
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Zusammenfassung:Aim To evaluate the association of antenatal corticosteroids (ACS) therapy on the risk for cystic periventricular leukomalacia (c‐PVL) in very low birth weight (VLBW), very preterm infants, whilst accounting for the occurrence of major neonatal morbidities; sepsis, necrotising enterocolitis, intraventricular haemorrhage and bronchopulmonary dysplasia. Methods Population‐based observational cohort study applying data collected by the Israel national VLBW infant database from 1995–2016. Results Cystic PVL was diagnosed in 692 (6.8%) of the 10,170 study infants. Among 7522 infants exposed to ACS, the rate of c‐PVL was 5.4%, compared to 10.7% among those not exposed (p 
ISSN:0803-5253
1651-2227
DOI:10.1111/apa.15772