The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa: Results of a prospective European cohort study

The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa: Results of a prospective European cohort study

Tetracyclines and clindamycin plus rifampicin combination therapy are both considered first-line therapy in current hidradenitis suppurativa guidelines. However, evidence for their efficacy is drawn from small studies, often without validated outcomes. To assess the 12-week efficacy of oral tetracyc...

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Veröffentlicht in:Journal of the American Academy of Dermatology 2021-08, Vol.85 (2), p.369-378
Hauptverfasser: van Straalen, Kelsey R., Tzellos, Thrasyvoulos, Guillem, Phillipe, Benhadou, Farida, Cuenca-Barrales, Carlos, Daxhelet, Mathilde, Daoud, Mathieu, Efthymiou, Ourania, Giamarellos-Bourboulis, Evangelos J., Jemec, Gregor B.E., Katoulis, Alexandros C., Koenig, Anke, Lazaridou, Elizabeth, Marzano, Angelo V., Matusiak, Łucas, Molina-Leyva, Alejandro, Moltrasio, Chiara, Pinter, Andreas, Potenza, Concetta, Romaní, Jorge, Saunte, Ditte M., Skroza, Nevena, Stergianou, Dimitra, Szepietowski, Jacek, Trigoni, Anastasia, Vilarrasa, Eva, van der Zee, Hessel H.
Format: Artikel
Sprache:eng
Schlagworte:
acne inversa
antibiotics
clindamycin
doxycycline
efficacy
guideline
minocycline
outcome
rifampicin
tetracycline
therapy
treatment
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Zusammenfassung:Tetracyclines and clindamycin plus rifampicin combination therapy are both considered first-line therapy in current hidradenitis suppurativa guidelines. However, evidence for their efficacy is drawn from small studies, often without validated outcomes. To assess the 12-week efficacy of oral tetracyclines and a combination of clindamycin and rifampicin. A prospective, international cohort study performed between October 2018 and August 2019. In total, 63.6% of the included 283 patients received oral tetracyclines, and 36.4% were treated with clindamycin and rifampicin. Both groups showed a significant decrease in International Hidradenitis Suppurativa Severity Score System from baseline (both P 
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2020.12.089