Outcomes of Intravenous Chemotherapy (Chemoreduction) for Retinoblastoma Based on Patient Age in 964 Eyes of 554 Patients

Outcomes of Intravenous Chemotherapy (Chemoreduction) for Retinoblastoma Based on Patient Age in 964 Eyes of 554 Patients

To evaluate retinoblastoma control after intravenous chemotherapy (chemoreduction) by patient age at presentation. Retrospective case series. This study included 964 eyes of 554 patients treated with chemoreduction at Ocular Oncology Service at Wills Eye Hospital. Patients received 6 monthly cycles...

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Veröffentlicht in:Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) Pa.), 2021-01, Vol.10 (4), p.373-380
Hauptverfasser: Bas, Zeynep, Dalvin, Lauren A., Tadepalli, Sameeksha, Rao, Raksha, Shah, Amish, Leahey, Ann M., Shields, Carol L.
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carboplatin
Child, Preschool
Combined Modality Therapy
Etoposide
Eye Enucleation
Humans
Infant
Neoplasm Recurrence, Local
Retinal Neoplasms - drug therapy
Retinoblastoma - drug therapy
Retrospective Studies
Vincristine
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Zusammenfassung:To evaluate retinoblastoma control after intravenous chemotherapy (chemoreduction) by patient age at presentation. Retrospective case series. This study included 964 eyes of 554 patients treated with chemoreduction at Ocular Oncology Service at Wills Eye Hospital. Patients received 6 monthly cycles of standard chemoreduction. Additional therapies for tumor control were performed as needed. Of 964 eyes, a comparison by age group (24 months) revealed more advanced age group with higher frequency of group E tumor (15% vs. 25% vs. 32% vs. 39%, P 
ISSN:2162-0989
2162-0989
DOI:10.1097/APO.0000000000000360