Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019–compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing:...

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Veröffentlicht in:The Journal of pediatrics 2021-05, Vol.232, p.287-289.e4
Hauptverfasser: Villaverde, Serena, Domínguez-Rodríguez, Sara, Sabrido, Gema, Romero, María Pilar, Grasa, Carlos Daniel, Jiménez, Ana Belén, Heras, Elena, Núñez, María del Mar, Illán, Marta, Soto, Beatriz, Mendoza, Pablo, Gijón, Manuel, Pérez-Moneo, Begoña, Moraleda, Cinta, Tagarro, Alfredo, del Rosal, Teresa, Santos, Mar, Rincón, Elena, Santiago, Begoña, Saavedra-Lozano, Jesús, Aguilera-Alonso, David, Epalza, Cristina, Rojo, Pablo, Calleja, Gero, de la Torre, Mercedes, Sanz-Santaeufemia, F.J., Herrero, B., Alonso, M., Soriano-Arandes, Toni, Pujol, J.M., Soler-Palacin, Pere, Lanaspa, Miguel, Urretavizcaya, M., Herranz, Mercedes, Ara, Fatima, Cabañas, Santiago, Vázquez, José Luis, Falcón, Lola, Neth, Olaf, Goicoechea, Walter, Figueroa, Lucía, García, Claudia, Alvaredo, Teresa, Olmedo, Ma Inmaculada, López, Agustín, Cobo, Elvira, Galán, Pilar, Guillén, Sara, Navas, Adriana, Pérez, Sara, Hernández, María José, Berzosa, Arantxa, Ruiz, Beatriz, Alfayate, Santiago, Menasalvas, Ana, Cervantes, Eloísa, Méndez, María, Hurtado, Ángela, Oltra, Manuel, Villaroya, Álvaro, Ocaña, Angustias, Guzmán, María Fernanda, Pascual, M.J., Sánchez-Códez, María, Montesinos, Elena, Jensen, Julia, Rodríguez, María, Caro, Gloria, Gómez, Alba, Bretón, Rafael, Rodríguez, Margarita, Romero, Julio, Campos, Ana, García, Mercedes, Velasco, Rosa María, Lobato, Zulema, Rey, Corsino, Vivanco, Ana, Alcalá, Pedro, Solé, Eduard, Minguell, Laura, Astigarraga, Itziar, Vázquez, Ma Ángeles, Díaz, Elena, Consuegra, Eduardo, Cabanillas, María, Peña, Luis, Garrote, Elisa, Goicoechea, Maite, Centelles, Irene, Gutiérrez, Sara, Cavalle, Amparo, Olmos, José María, Cobo, Alejandro, Díaz, Sara, Jiménez, Beatriz, Lafuente, Miguel, Pons, Natividad, Morata, Julia, Segura, Elsa
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
antigen test
Antigens, Viral - analysis
Brief Reports
Child
Child, Preschool
COVID-19
COVID-19 - diagnosis
COVID-19 - virology
DNA, Viral - analysis
Female
Humans
Infant
Infant, Newborn
Male
Nasopharynx - virology
Pandemics
PCR
Reproducibility of Results
Reverse Transcriptase Polymerase Chain Reaction - methods
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
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Zusammenfassung:We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019–compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2021.01.027