Serum hepatitis B core‐related antigen level stratifies risk of disease progression in chronic hepatitis B patients with intermediate viral load

Summary Background Patients with chronic hepatitis B virus (HBV) infection are at risk of developing liver disease. Serum hepatitis B core‐related antigen (HBcrAg) is a new biomarker for intrahepatic templates for HBV replication. Aim To explore whether a high HBcrAg level is associated with increas...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2021-04, Vol.53 (8), p.908-918
Hauptverfasser:	Tseng, Tai‐Chung, Liu, Chun‐Jen, Yang, Wan‐Ting, Hsu, Chen‐Yang, Hong, Chun‐Ming, Su, Tung‐Hung, Tsai, Cheng‐Hsueh, Chen, Chi‐Ling, Yang, Hung‐Chih, Liu, Chen‐Hua, Chen, Hsiu‐Hsi, Chen, Pei‐Jer, Kao, Jia‐Horng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Antigens Chronic infection Cirrhosis Deoxyribonucleic acid Disease Progression DNA DNA, Viral Hepatitis B Hepatitis B Core Antigens Hepatitis B e antigen Hepatitis B e Antigens Hepatitis B virus - genetics Hepatitis B, Chronic - complications Humans Interferon Liver cirrhosis Liver diseases Risk assessment Symptom Flare Up Viral Load
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Zusammenfassung:	Summary Background Patients with chronic hepatitis B virus (HBV) infection are at risk of developing liver disease. Serum hepatitis B core‐related antigen (HBcrAg) is a new biomarker for intrahepatic templates for HBV replication. Aim To explore whether a high HBcrAg level is associated with increased risk of cirrhosis, especially in patients with intermediate viral load (HBV DNA 2000‐19 999 IU/mL) due to their moderate risk of disease progression. Methods A total of 1673 treatment‐naïve, non‐cirrhotic patients with negative hepatitis B e antigen (HBeAg) and alanine aminotransferase (ALT) level
ISSN:	0269-2813 1365-2036
DOI:	10.1111/apt.16266