Epicardial adipose tissue modulates arrhythmogenesis in right ventricle outflow tract cardiomyocytes

Epicardial adipose tissue modulates arrhythmogenesis in right ventricle outflow tract cardiomyocytes

Abstract Aims Ventricular arrhythmia (VA) frequently occurs in fatty infiltrative cardiomyopathy or epicardial adipose tissue (EAT) abundant hearts. Right ventricular outflow tract (RVOT), commonly covered with EAT, is vital for VA genesis. This study explored whether EAT contributes to RVOT arrhyth...

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Veröffentlicht in:Europace (London, England) England), 2021-06, Vol.23 (6), p.970-977
Hauptverfasser: Lu, Yen-Yu, Huang, Shih-Yu, Lin, Yung-Kuo, Chen, Yao-Chang, Chen, Yi-Ann, Chen, Shih-Ann, Chen, Yi-Jen
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Sprache:eng
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Zusammenfassung:Abstract Aims Ventricular arrhythmia (VA) frequently occurs in fatty infiltrative cardiomyopathy or epicardial adipose tissue (EAT) abundant hearts. Right ventricular outflow tract (RVOT), commonly covered with EAT, is vital for VA genesis. This study explored whether EAT contributes to RVOT arrhythmogenesis. Methods and results Conventional microelectrodes and whole-cell patch clamp were used to record electrical activity and ionic currents in rabbit RVOT tissue preparation or isolated single cardiomyocytes with or without (control) connected EAT. Epicardial adipose tissue-connected (N = 6) RVOT had more portions of fibrosis than did control (N = 5) RVOT (160.3 ± 23.2 vs. 91.9 ± 13.4 μm2/mm2, P 
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/euaa412