Dynamic Self-Organization of Idealized Migrating Cells by Contact Communication

This Letter investigates what forms of cellular dynamic self-organization are caused through intercellular contact communication based on a theoretical model in which migrating cells perform contact following and contact inhibition and attraction of locomotion. Tuning those strengths causes varieties of dynamic patterns. This further includes a novel form of collective migration, snakelike dynamic assembly. Scrutinizing this pattern reveals that cells in this state can accurately respond to an external directional cue but have no spontaneous global polar order.