Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method
We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DN...
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Veröffentlicht in: | Bulletin of experimental biology and medicine 2021, Vol.170 (3), p.303-307 |
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creator | Timoshin, A. A. Shumaev, K. B. Lakomkin, V. L. Abramov, A. A. Ruuge, E. K. |
description | We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DNIC-Acc administration significantly increased the total level of NO in the lung and liver tissues of the animal, which was accompanied by a slight decrease in the mean BP ( |
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subjects | Biomedical and Life Sciences Biomedicine Biophysics and Biochemistry Cell Biology Cysteine Electron spin resonance Internal Medicine Iron Laboratory Medicine Lipophilic Methods N-Acetyl-L-cysteine Pathology Skin Spectroscopy |
title | Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method |
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