Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method

Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method

We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DN...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2021, Vol.170 (3), p.303-307
Hauptverfasser: Timoshin, A. A., Shumaev, K. B., Lakomkin, V. L., Abramov, A. A., Ruuge, E. K.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
Cysteine
Electron spin resonance
Internal Medicine
Iron
Laboratory Medicine
Lipophilic
Methods
N-Acetyl-L-cysteine
Pathology
Skin
Spectroscopy
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Zusammenfassung:We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DNIC-Acc administration significantly increased the total level of NO in the lung and liver tissues of the animal, which was accompanied by a slight decrease in the mean BP (
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05056-z