Age Peculiarities of Respiratory Activity and Membrane Microviscosity of Mitochondria from Rat Cardiomyocytes

Age Peculiarities of Respiratory Activity and Membrane Microviscosity of Mitochondria from Rat Cardiomyocytes

We studied respiratory activity and microviscosity of mitochondrial membranes from the left ventricular myocardium of 2-month-old ( n =8) and 15-month-old ( n =8) rats. The respiratory control (RC) during substrate phosphorylation was calculated as the ratio of oxygen absorption rates in the presenc...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2021, Vol.170 (3), p.368-370
Hauptverfasser: Rebrova, T. Yu, Korepanov, V. A., Afanasiev, S. A.
Format: Artikel
Sprache:eng
Schlagworte:
Age
Biogerontology
Biomedical and Life Sciences
Biomedicine
Cardiomyocytes
Cell Biology
Heart
Internal Medicine
Laboratory Medicine
Lipids
Mitochondria
Myocardium
Pathology
Phosphorylation
Proteins
Pyrene
Respiration
Structure-function relationships
Ventricle
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Zusammenfassung:We studied respiratory activity and microviscosity of mitochondrial membranes from the left ventricular myocardium of 2-month-old ( n =8) and 15-month-old ( n =8) rats. The respiratory control (RC) during substrate phosphorylation was calculated as the ratio of oxygen absorption rates in the presence of ADP and after its utilization. In 2-month-old rats, RC was 4.66 (4.56; 4.71); in 15-month-old animals, it was significantly ( р
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05069-8