Impact of seasonality, storage of semen, and sperm head‐shape on whole tissue methylation and expression of methylation responsive candidate genes in swine placenta and fetal livers from summer and winter breedings
Epigenetics includes the study of external factors that can influence the expression of genes by altering the accessibility of DNA through methylation. To investigate the epigenetic influence of season, sperm head shape, and semen storage on placental and fetal tissues, pregnancies were generated in...
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| Veröffentlicht in: | Molecular reproduction and development 2019-04, Vol.86 (4), p.465-475 |
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| creator | Rempel, Lea A. Krautkramer, Megan M. Parrish, John J. Miles, Jeremy R. |
| description | Epigenetics includes the study of external factors that can influence the expression of genes by altering the accessibility of DNA through methylation. To investigate the epigenetic influence of season, sperm head shape, and semen storage on placental and fetal tissues, pregnancies were generated in the summer or winter using boar semen from either least or most sperm head shape change, collected during cool or warm seasons, and stored as cooled‐extended or cryopreserved. The lowest (p |
| doi_str_mv | 10.1002/mrd.23125 |
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CDH1 tended (
p < 0.10) to be greater in placenta generated from cryopreserved semen or semen collected during cool periods. The relative expression of placental
GNAS was affected (
p < 0.05) by the interaction of breeding and semen collection seasons. Cryopreserved semen increased (
p < 0.05) the placental relative expression of
GNAS. Placental
MEST and
RHOBTB3 tended (
p < 0.10) to have a greater relative expression from pregnancies generated using semen collected during cool periods used during winter breedings. Within fetal liver, the relative expression of
GNAS and
HGF was greater (
p < 0.05) from winter breedings. Interaction of winter breedings and least sperm head shape change tended (
p < 0.10) to have the greatest fetal liver expression of
CDH1. Seasonality of semen collection, breeding, and the effect on sperm head shape change had an influence on the expression of genes with known differentially methylated regions or response to methylation activity from embryonic and extraembryonic tissues.
Highlight
Methylation activity is dynamic throughout embryonic and extraembryonic development. Influence of season putatively alters the methylation profile and gene expression within placental and fetal livers of swine.]]></description><identifier>ISSN: 1040-452X</identifier><identifier>EISSN: 1098-2795</identifier><identifier>DOI: 10.1002/mrd.23125</identifier><identifier>PMID: 30767330</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; boars ; Breeding ; Cryopreservation ; cryopreserved semen ; DNA ; DNA Methylation ; E-cadherin ; Embryogenesis ; Epigenesis, Genetic ; Epigenetics ; Female ; fertility ; Fetus - cytology ; Fetus - embryology ; Fetuses ; Gene expression ; genes ; Liver ; Liver - cytology ; Liver - embryology ; Livestock ; Male ; methylation ; Placenta ; Placenta - cytology ; Placenta - metabolism ; Pregnancy ; season ; Seasonal variations ; Seasons ; Semen ; Semen Preservation ; Sperm ; Sperm Head - metabolism ; Sperm Motility ; spermatozoa ; Storage ; Summer ; Swine ; Tissues ; Winter</subject><ispartof>Molecular reproduction and development, 2019-04, Vol.86 (4), p.465-475</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3865-95d8af3f95ae7342e6697b67e4abf8c755a757fbbea3f7848fbc6f7d2bae1653</citedby><cites>FETCH-LOGICAL-c3865-95d8af3f95ae7342e6697b67e4abf8c755a757fbbea3f7848fbc6f7d2bae1653</cites><orcidid>0000-0003-4765-8400 ; 0000-0002-8344-5085</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrd.23125$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrd.23125$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30767330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rempel, Lea A.</creatorcontrib><creatorcontrib>Krautkramer, Megan M.</creatorcontrib><creatorcontrib>Parrish, John J.</creatorcontrib><creatorcontrib>Miles, Jeremy R.</creatorcontrib><title>Impact of seasonality, storage of semen, and sperm head‐shape on whole tissue methylation and expression of methylation responsive candidate genes in swine placenta and fetal livers from summer and winter breedings</title><title>Molecular reproduction and development</title><addtitle>Mol Reprod Dev</addtitle><description><![CDATA[Epigenetics includes the study of external factors that can influence the expression of genes by altering the accessibility of DNA through methylation. To investigate the epigenetic influence of season, sperm head shape, and semen storage on placental and fetal tissues, pregnancies were generated in the summer or winter using boar semen from either least or most sperm head shape change, collected during cool or warm seasons, and stored as cooled‐extended or cryopreserved. The lowest (p < 0.05) ratios of 5‐methylcytosine to 5‐hydroxymethylcytosine activity (5mC:5hmC) in fetal liver were from summer breedings and in placental tissues from winter breedings. The relative expression of placental
CDH1 tended (
p < 0.10) to be greater in placenta generated from cryopreserved semen or semen collected during cool periods. The relative expression of placental
GNAS was affected (
p < 0.05) by the interaction of breeding and semen collection seasons. Cryopreserved semen increased (
p < 0.05) the placental relative expression of
GNAS. Placental
MEST and
RHOBTB3 tended (
p < 0.10) to have a greater relative expression from pregnancies generated using semen collected during cool periods used during winter breedings. Within fetal liver, the relative expression of
GNAS and
HGF was greater (
p < 0.05) from winter breedings. Interaction of winter breedings and least sperm head shape change tended (
p < 0.10) to have the greatest fetal liver expression of
CDH1. Seasonality of semen collection, breeding, and the effect on sperm head shape change had an influence on the expression of genes with known differentially methylated regions or response to methylation activity from embryonic and extraembryonic tissues.
Highlight
Methylation activity is dynamic throughout embryonic and extraembryonic development. Influence of season putatively alters the methylation profile and gene expression within placental and fetal livers of swine.]]></description><subject>Animals</subject><subject>boars</subject><subject>Breeding</subject><subject>Cryopreservation</subject><subject>cryopreserved semen</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>E-cadherin</subject><subject>Embryogenesis</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Female</subject><subject>fertility</subject><subject>Fetus - cytology</subject><subject>Fetus - embryology</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>genes</subject><subject>Liver</subject><subject>Liver - cytology</subject><subject>Liver - embryology</subject><subject>Livestock</subject><subject>Male</subject><subject>methylation</subject><subject>Placenta</subject><subject>Placenta - cytology</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>season</subject><subject>Seasonal variations</subject><subject>Seasons</subject><subject>Semen</subject><subject>Semen Preservation</subject><subject>Sperm</subject><subject>Sperm Head - metabolism</subject><subject>Sperm Motility</subject><subject>spermatozoa</subject><subject>Storage</subject><subject>Summer</subject><subject>Swine</subject><subject>Tissues</subject><subject>Winter</subject><issn>1040-452X</issn><issn>1098-2795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQhyMEoqVw4AWQJS4gNa3jxHZyROVfpSIk1AO3aJKMd13FTvA4LHvjEXg8zjwJ3t2CEBLi5PHMN99lfln2uOBnBefi3IXhTJSFkHey44I3dS50I-_u6ornlRQfj7IHRDec86ap-f3sqORa6bLkx9n3SzdDH9lkGCHQ5GG0cXvKKE4BVnjoO_SnDPzAaMbg2Bph-PH1G61hToBnm_U0IouWaEHmMK63I0SbBrsV_DIHJNp9k-vPaWrPkyf7GVmfSDtARLZCj8SsZ7SxHtk8Qo8-wl5lMMLIxrQQiJkwOUaLcxj2w4THVHYBcbB-RQ-zewZGwke370l2_frV9cXb_Or9m8uLF1d5X9ZK5o0cajClaSSgLiuBSjW6Uxor6EzdaylBS226DqE0uq5q0_XK6EF0gIWS5Un27KCdw_RpQYqts9TjOILHaaFWVForobWs_48K3qh0z6ZI6NO_0JtpCek2e0oLLZRQiXp-oPowEQU07Rysg7BtC97ugtGmYLT7YCT2ya1x6RwOv8lfSUjA-QHY2BG3_za17z68PCh_AirvyJs</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Rempel, Lea A.</creator><creator>Krautkramer, Megan M.</creator><creator>Parrish, John J.</creator><creator>Miles, Jeremy R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-4765-8400</orcidid><orcidid>https://orcid.org/0000-0002-8344-5085</orcidid></search><sort><creationdate>201904</creationdate><title>Impact of seasonality, storage of semen, and sperm head‐shape on whole tissue methylation and expression of methylation responsive candidate genes in swine placenta and fetal livers from summer and winter breedings</title><author>Rempel, Lea A. ; Krautkramer, Megan M. ; Parrish, John J. ; Miles, Jeremy R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3865-95d8af3f95ae7342e6697b67e4abf8c755a757fbbea3f7848fbc6f7d2bae1653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>boars</topic><topic>Breeding</topic><topic>Cryopreservation</topic><topic>cryopreserved semen</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>E-cadherin</topic><topic>Embryogenesis</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Female</topic><topic>fertility</topic><topic>Fetus - cytology</topic><topic>Fetus - embryology</topic><topic>Fetuses</topic><topic>Gene expression</topic><topic>genes</topic><topic>Liver</topic><topic>Liver - cytology</topic><topic>Liver - embryology</topic><topic>Livestock</topic><topic>Male</topic><topic>methylation</topic><topic>Placenta</topic><topic>Placenta - cytology</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>season</topic><topic>Seasonal variations</topic><topic>Seasons</topic><topic>Semen</topic><topic>Semen Preservation</topic><topic>Sperm</topic><topic>Sperm Head - metabolism</topic><topic>Sperm Motility</topic><topic>spermatozoa</topic><topic>Storage</topic><topic>Summer</topic><topic>Swine</topic><topic>Tissues</topic><topic>Winter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rempel, Lea A.</creatorcontrib><creatorcontrib>Krautkramer, Megan M.</creatorcontrib><creatorcontrib>Parrish, John J.</creatorcontrib><creatorcontrib>Miles, Jeremy R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Molecular reproduction and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rempel, Lea A.</au><au>Krautkramer, Megan M.</au><au>Parrish, John J.</au><au>Miles, Jeremy R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of seasonality, storage of semen, and sperm head‐shape on whole tissue methylation and expression of methylation responsive candidate genes in swine placenta and fetal livers from summer and winter breedings</atitle><jtitle>Molecular reproduction and development</jtitle><addtitle>Mol Reprod Dev</addtitle><date>2019-04</date><risdate>2019</risdate><volume>86</volume><issue>4</issue><spage>465</spage><epage>475</epage><pages>465-475</pages><issn>1040-452X</issn><eissn>1098-2795</eissn><abstract><![CDATA[Epigenetics includes the study of external factors that can influence the expression of genes by altering the accessibility of DNA through methylation. To investigate the epigenetic influence of season, sperm head shape, and semen storage on placental and fetal tissues, pregnancies were generated in the summer or winter using boar semen from either least or most sperm head shape change, collected during cool or warm seasons, and stored as cooled‐extended or cryopreserved. The lowest (p < 0.05) ratios of 5‐methylcytosine to 5‐hydroxymethylcytosine activity (5mC:5hmC) in fetal liver were from summer breedings and in placental tissues from winter breedings. The relative expression of placental
CDH1 tended (
p < 0.10) to be greater in placenta generated from cryopreserved semen or semen collected during cool periods. The relative expression of placental
GNAS was affected (
p < 0.05) by the interaction of breeding and semen collection seasons. Cryopreserved semen increased (
p < 0.05) the placental relative expression of
GNAS. Placental
MEST and
RHOBTB3 tended (
p < 0.10) to have a greater relative expression from pregnancies generated using semen collected during cool periods used during winter breedings. Within fetal liver, the relative expression of
GNAS and
HGF was greater (
p < 0.05) from winter breedings. Interaction of winter breedings and least sperm head shape change tended (
p < 0.10) to have the greatest fetal liver expression of
CDH1. Seasonality of semen collection, breeding, and the effect on sperm head shape change had an influence on the expression of genes with known differentially methylated regions or response to methylation activity from embryonic and extraembryonic tissues.
Highlight
Methylation activity is dynamic throughout embryonic and extraembryonic development. Influence of season putatively alters the methylation profile and gene expression within placental and fetal livers of swine.]]></abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30767330</pmid><doi>10.1002/mrd.23125</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4765-8400</orcidid><orcidid>https://orcid.org/0000-0002-8344-5085</orcidid></addata></record> |
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| ispartof | Molecular reproduction and development, 2019-04, Vol.86 (4), p.465-475 |
| issn | 1040-452X 1098-2795 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals boars Breeding Cryopreservation cryopreserved semen DNA DNA Methylation E-cadherin Embryogenesis Epigenesis, Genetic Epigenetics Female fertility Fetus - cytology Fetus - embryology Fetuses Gene expression genes Liver Liver - cytology Liver - embryology Livestock Male methylation Placenta Placenta - cytology Placenta - metabolism Pregnancy season Seasonal variations Seasons Semen Semen Preservation Sperm Sperm Head - metabolism Sperm Motility spermatozoa Storage Summer Swine Tissues Winter |
| title | Impact of seasonality, storage of semen, and sperm head‐shape on whole tissue methylation and expression of methylation responsive candidate genes in swine placenta and fetal livers from summer and winter breedings |
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