Soluble DC-SIGN isoforms: Ligands with unknown functions - A mini-review

The present study aimed to perform a mini-review of the complete soluble isoforms of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (sDC-SIGN), their functions, and their correlation with diseases. The present review reveals the lack of studies regarding these soluble isoforms and poor understanding of the importance of the topic, considering the concordant findings on the relevant influence of sDC-SIGN in the viral and bacterial infection process, in addition to its possible use as a cancer marker. •sDC-SIGN cannot modulate IL-2 production from primary human CD4 T-cells.•sDC-SIGN can interfere in the HIV, CMV, and S. aureus infection process.•sDC-SIGN is a marker for colon cancer screening and prognosis in early-stage patients.