Post-hoc analysis of pegloticase pivotal trials in chronic refractory gout: relationship between fluctuations in plasma urate levels and acute flares

Post-hoc analysis of pegloticase pivotal trials in chronic refractory gout: relationship between fluctuations in plasma urate levels and acute flares

To determine factors associated with gout flares in subjects treated with pegloticase. Gout flares from two randomised controlled trials comparing pegloticase (8 mg every 2 weeks [q2] or monthly [q4]) versus placebo were analysed. Responders had persistent urate lowering (

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Bibliographische Detailangaben
Veröffentlicht in:Clinical and Experimental Rheumatology 2021-09, Vol.39 (5), p.1085-1092
Hauptverfasser: Mandell, Brian F, Fields, Theodore R, Edwards, N Lawrence, Yeo, Anthony E, Lipsky, Peter E
Format: Artikel
Sprache:eng
Schlagworte:
Chronic Disease
Gout - drug therapy
Gout Suppressants - therapeutic use
Humans
Polyethylene Glycols
Symptom Flare Up
Urate Oxidase
Uric Acid
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Zusammenfassung:To determine factors associated with gout flares in subjects treated with pegloticase. Gout flares from two randomised controlled trials comparing pegloticase (8 mg every 2 weeks [q2] or monthly [q4]) versus placebo were analysed. Responders had persistent urate lowering (
ISSN:0392-856X
1593-098X
DOI:10.55563/clinexprheumatol/b7jjnb