Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway

A methanol extract from Isodonis Herba demonstrated significant proliferative effect on human hair follicle dermal papilla cells (HFDPC, % of control: 150.0 ± 2.0% at 20 µg/mL, p

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural medicines 2021-03, Vol.75 (2), p.326-338
Hauptverfasser:	Manse, Yoshiaki, Luo, Fenglin, Kato, Kazuhiro, Okazaki, Akane, Okada-Nishida, Eriko, Yanagida, Mitsuhiro, Nakamura, Sho, Morikawa, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antifungal agents beta Catenin - metabolism Biomedical and Life Sciences Biomedicine Cell Proliferation Chemistry, Medicinal Complementary & Alternative Medicine Diterpenes Diterpenes, Kaurane - metabolism Flowers & plants Follicles Glycogen Synthase Kinase 3 beta - metabolism Hair Follicle - metabolism Humans Life Sciences & Biomedicine Medicinal Chemistry mRNA Original Paper Pharmacology & Pharmacy Pharmacology/Toxicology Pharmacy Phytochemicals Plant Sciences Proto-Oncogene Proteins c-akt - metabolism Science & Technology Triterpenoids Vascular endothelial growth factor β-Catenin
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Beschreibung
Zusammenfassung:	A methanol extract from Isodonis Herba demonstrated significant proliferative effect on human hair follicle dermal papilla cells (HFDPC, % of control: 150.0 ± 2.0% at 20 µg/mL, p
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-020-01477-8